Technical library

11/05/2010 - Maximizing $$$ and Purity in Peptide Synthesis: The Hybrid Process

  As the demand for longer, more complex synthetically produced peptides has increased, so too have the methods of producing these peptides adapted in order to achieve high results even at the commercial scale.   One such method that employs the Fmoc/t-butyl protecting scheme is the hybrid or fragment condensation method.   The hybrid process takes advantage […]

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26/02/2010 - Comparison of Fmoc-(Trt) and Fmoc-(t-Bu) Amino Acid Protection

Side chain functionalities in Fmoc solid phase synthesis are routinely protected by mild acid labile protecting groups. The foremost choice among these are t-butyl (t-Bu) and trityl (Trt) based groups. In certain situations, the trityl based groups offer distinct advantages over the t-butyl based groups. The following advantages occur: If a side chain derivatized peptide […]

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28/01/2010 - D-Amino Acids at CBL

The use of D-amino acids is no longer reserved for research and development. D-amino acids are now frequently incorporated in peptide pharmaceuticals. For example, Goserelin (Zoladex), which contains a D-Ser(t-Bu) in its sequence, has been a commercial success in the treatment of prostate cancer. Also, the use of D-amino acids in Bivalirudin and Icatibant has […]

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05/01/2010 - The Abundant Versatility of the 4-Methoxytrityl Group

 One of the most versatile cysteine side chain protecting groups in Fmoc based solid phase synthesis is the 4-Methoxytrityl group (Mmt).  The protecting group can be very readily introduced onto the cystine (cys) side chain by the reaction with 4-methoxytrityl chloride with cysteine hydrochloride hydrate. The Mmt group is highly acid sensitive (1). Mmt can […]

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10/11/2009 - Usage of Trityl Linkers

The convergent (or fragment condensation) method for the solid phase synthesis of peptides and large amounts of pharmaceutical grade peptides, is rapidly becoming the method of choice (1). Using Fmoc/tBu protected amino acids, in combination with the 2-chlorotrityl chloride resin, confers certain advantages for the synthesis of protected peptide fragments. The linkage is particularly acid […]

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10/11/2009 - Utility of Trityl Supports in Fmoc-t-butyl Solid Phase Peptide Synthesis

The utility of the 2-chlorotrityl-chloride supports in Fmoc-t-butyl solid phase synthesis has been widely recognized for its unique properties CBL was founded on the discovery and development of several key innovations including the trityl resins. CBL is one of the largest global suppliers of peptide synthesis materials, including trityl resins, preloaded trityl resins, Fmoc-amino acids […]

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14/10/2009 - CBL Company Brief

Company Profile Download CBL’s company brief.

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